STING modulator-3

• Description :

  STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells[1].

• UNSPSC :

  12352005

• Target :

  STING

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/sting-modulator-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N#CCN1N=C(C)C=C1C2=CN(C)C(C3=NC(C(N)=O)=CC4=C3C=NN4C)=N2

• Molecular Formula :

  C18H17N9O

• Molecular Weight :

  375.39

• References & Citations :

  [1]Gajiwala KS, et al. Imidazole derivatives as STING modulators and their preparation, pharmaceutical compositions and use in the treatment of cancer: World Intellectual Property Organization, WO2022195462. 2022-09-22.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2839639-94-8]