STING modulator-3

STING modulator-3

• CAS Number: 2839639-94-8
• UNSPSC Description: STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells[1].
• Target Antigen: STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sting-modulator-3.html
• Solubility: 10 mM in DMSO
• Smiles: N#CCN1N=C(C)C=C1C2=CN(C)C(C3=NC(C(N)=O)=CC4=C3C=NN4C)=N2
• Molecular Weight: 375.39
• References & Citations: [1]Gajiwala KS, et al. Imidazole derivatives as STING modulators and their preparation, pharmaceutical compositions and use in the treatment of cancer: World Intellectual Property Organization, WO2022195462. 2022-09-22.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported