STING modulator-3

• UNSPSC Description:

  STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells[1].

• Target Antigen:

  STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sting-modulator-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CCN1N=C(C)C=C1C2=CN(C)C(C3=NC(C(N)=O)=CC4=C3C=NN4C)=N2

• Molecular Weight:

  375.39

• References & Citations:

  [1]Gajiwala KS, et al. Imidazole derivatives as STING modulators and their preparation, pharmaceutical compositions and use in the treatment of cancer: World Intellectual Property Organization, WO2022195462. 2022-09-22.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2839639-94-8