MGluR2 modulator 3

• Description:

  MGluR2 modulator 3 (compound 1) is a potent mGluR2 positive allosteric modulator with an EC50 value of 0.87 μM. mGluR2 modulator 3 has activity in psychosis disease models such as methamphetamine-induced hyperactivity and mescaline-induced scratching in mice[1].

• UNSPSC:

  12352005

• Target:

  MGluR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mglur2-modulator-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1C2=CC=CC=C2N=C1CN3CCC(CC3)C4=CC=CC=C4OC

• Molecular Formula:

  C21H25N3O

• Molecular Weight:

  335.44

• References & Citations:

  [1]Szabó G, et al. Discovery of dihydropyrazino-benzimidazole derivatives as metabotropic glutamate receptor-2 (mGluR2) positive allosteric modulators (PAMs) . Eur J Med Chem. 2020;186:111881.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR2

• CAS Number:

  [1004614-58-7]