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Nur77 modulator 2

CAT: 0804-HY-115923Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-115923Size:1 Each
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Description
Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1].
CAS Number
[2055829-03-1]
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nur77-modulator-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(C2=CC(C3=CC(O)=CC(C4(C5)CC6CC5CC(C6)C4)=C3O2)=O)C=C1
Molecular Formula
C26H25NO5
Molecular Weight
431.48
References & Citations
[1]Mingtao Ao, et al. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorg Chem. 2022 Jan 29;120:105645.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1

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