Nur77 modulator 2

• UNSPSC Description:

  Nur77 modulator 2, a Nur77 modulator (Kd of 0.35 μM), is a potent and orally active inflammation inhibitor. Nur77 modulator 2 modulates the colocalization of Nur77 at mitochondria[1].

• Target Antigen:

  Nuclear Hormone Receptor 4A/NR4A

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nur77-modulator-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NO)C1=CC=C(C2=CC(C3=CC(O)=CC(C4(C5)CC6CC5CC(C6)C4)=C3O2)=O)C=C1

• Molecular Weight:

  431.48

• References & Citations:

  [1]Mingtao Ao, et al. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorg Chem. 2022 Jan 29;120:105645.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2055829-03-1