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Nur77 modulator 1

CAT: 0804-HY-131364-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131364-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nur77 modulator 1 is a good Nur77 binder (KD = 3.58 μM) . Nur77 modulator 1 up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis. Anti-hepatoma activity[1].
CAS Number
2469975-55-9
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Apoptosis; Nuclear Hormone Receptor 4A/NR4A
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nur77-modulator-1.html
Purity
98.61
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=NC2=C(OC)C=CC=C2C(NC3=CC4=C(NC(C(N/N=C/C5=CC=C(SC)C=C5)=O)=C4)C=C3)=C1
Molecular Formula
C28H25N5O2S
Molecular Weight
495.60
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Baicun Li, et al. Design, synthesis, and biological evaluation of 5- ((8-methoxy-2-methylquinolin-4-yl) amino) -1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. Eur J Med Chem. 2020 Oct 15;204:112608.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nur77/NR4A1

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