Progranulin modulator-3

• UNSPSC Description:

  Progranulin modulator-3 (compd C40) is a brain-penetrant and orally active progranulin (PGRN) inducer. Progranulin modulator-3 can be used for neurological research[1].

• Target Antigen:

  Neurotensin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/progranulin-modulator-3.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C1=CC=CO1)NC2=CC=C3C(N=C(C4=CC=CC=C4)O3)=C2

• Molecular Weight:

  304.30

• References & Citations:

  [1]Tesla R, et al. Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nat Commun. 2024 Jul 20;15(1):6125.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  371116-39-1