Nur77 modulator 4

• Target:

  Apoptosis|||NR4A|||IRE1|||PERK

• Related Pathways:

  Endocrinology/Hormones|||Cell Cycle/Checkpoint|||Apoptosis

• Bioactivity:

  Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 ?M. It significantly promotes Nur77 expression and apoptosis, exhibiting excellent growth inhibitory effects on HepG2 and MCF-7 cells, with an IC50 of less than 5 ?M. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, leading to apoptosis. This compound is applicable in cancer research.

• Molecular Formula:

  C26H28ClN5O2

• Molecular Weight:

  477.99

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C