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Nur77 modulator 4

CAT: 0931-T205370-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205370-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, NR4A, IRE1, PERK
Related Pathways
Endocrinology/Hormones, Cell Cycle/Checkpoint, Apoptosis
Bioactivity
Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. It significantly promotes Nur77 expression and apoptosis, exhibiting excellent growth inhibitory effects on HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, leading to apoptosis. This compound is applicable in cancer research.
Molecular Formula
C26H28ClN5O2
Molecular Weight
477.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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