Nur77 modulator 3

• Target:

  Autophagy|||mTOR

• Related Pathways:

  Autophagy|||PI3K/Akt/mTOR signaling

• Bioactivity:

  Nur77 modulator 3 (9e) binds to Nur77 and inhibits TGF-?1-induced ?-SMA and COLA1 expression in a Nur77-dependent manner. It induces Nur77 expression and enhances autophagic flux by inhibiting the mTORC1 signaling pathway in vitro and in vivo. Nur77 modulator 3 blocks the progression of hepatic fibrosis [1].

• Smiles:

  C (=N/NC (NC1=CC=C (C) C=C1) =S) \C=2C=3C (NC2) =CC=CC3

• Molecular Formula:

  C17H16N4S

• Molecular Weight:

  308.4

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2097787-75-0