Nur77 modulator 3

• Target :

  Autophagy|||mTOR

• Related Pathways :

  Autophagy|||PI3K/Akt/mTOR signaling

• Bioactivity :

  Nur77 modulator 3 (9e) binds to Nur77 and inhibits TGF-?1-induced ?-SMA and COLA1 expression in a Nur77-dependent manner. It induces Nur77 expression and enhances autophagic flux by inhibiting the mTORC1 signaling pathway in vitro and in vivo. Nur77 modulator 3 blocks the progression of hepatic fibrosis [1].

• Smiles :

  C(=N/NC(NC1=CC=C(C)C=C1)=S)\C=2C=3C(NC2)=CC=CC3

• Molecular Formula :

  C17H16N4S

• Molecular Weight :

  308.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2097787-75-0