MG degrader 1

MG degrader 1

• UNSPSC Description: MG degrader 1 (Compd E14) is a PROTAC degrader of IKZF3, GSPT1, and GSPT2 with an EC50 value of 1.385 nM in MM.1S cells[1].
• Target Antigen: IKZF Family; PROTACs
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mg-degrader-1.html
• Solubility: DMSO : 125 mg/mL (ultrasonic)
• Smiles: O=C1N(C2CCC(NC2=O)=O)C(C3=C(NCCCCNC(C(C4=CC=CC(OC)=C4)N(CC(C)C)C=O)=O)C=CC=C31)=O
• Molecular Weight: 591.65
• References & Citations: [1]Zefeng Wang, et al. Direct-to-biology, automated, nano-scale synthesis, and phenotypic screening-enabled E3 ligase modulator discovery. Nat Commun. 2023 Dec 19;14(1):8437.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported