eEF2K degrader-1

eEF2K degrader-1

• UNSPSC Description: eEF2K degrader-1c (compound 36) is a type of eEF2K degrader. eEF2K degrader-1 can inhibit the viability, proliferation, and migration of the MDA-MB-231 and HCC1806 cell lines, with an IC50 value of 43.71 nM for MDA-MB-231. eEF2K degrader-1 shows tumor-suppressing effects in mouse models with MDA-MB-231 cell xenografts[1].
• Target Antigen: CaMK
• Type: Reference compound
• Related Pathways: Neuronal Signaling
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/eef2k-degrader-1.html
• Smiles: CC1=C(C=CC(N2C(N(C(C(C(N3CCCCC3)=O)=N2)=O)CC4=CC=CC=C4)=O)=C1)C
• Molecular Weight: 418.49
• References & Citations: [1]Zhao X, et al. Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15837-15861.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported