eEF2K degrader-1

• UNSPSC Description:

  eEF2K degrader-1c (compound 36) is a type of eEF2K degrader. eEF2K degrader-1 can inhibit the viability, proliferation, and migration of the MDA-MB-231 and HCC1806 cell lines, with an IC50 value of 43.71 nM for MDA-MB-231. eEF2K degrader-1 shows tumor-suppressing effects in mouse models with MDA-MB-231 cell xenografts[1].

• Target Antigen:

  CaMK

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/eef2k-degrader-1.html

• Smiles:

  CC1=C(C=CC(N2C(N(C(C(C(N3CCCCC3)=O)=N2)=O)CC4=CC=CC=C4)=O)=C1)C

• Molecular Weight:

  418.49

• References & Citations:

  [1]Zhao X, et al. Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2H,4H)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15837-15861.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported