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ANXA3 degrader 1

CAT: 0804-HY-168950Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168950Size:1 Each
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Description
ANXA3 degrader 1 (Compound 18a5) is a highly selective ANXA3 degrader with cancer cell inhibition activity. ANXA3 degrader 1 displays excellent inhibitory effect in a triple-negative breast cancer (TNBC) tumor xenograft model (TGI=96%) [1].
UNSPSC
12352005
Target
Annexin A
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(C)N1C2=CC=CC=C2C(C3=CC=CC=C3)=NC(NC(SCC(N4CCN(C5=NC=CC=C5)CC4)=O)=S)C1=O
Molecular Formula
C30H32N6O2S2
Molecular Weight
572.74
References & Citations
[1]Liu K, et al. Discovery of a Novel 1,4-Benzodiazepine Derivative as a Highly Selective ANXA3 Degrader for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2025 Mar 13;68 (5) :5358-5381.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AnxA3

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