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IKZF2-degrader 1

CAT: 0804-HY-172882Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172882Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IKZF2-degrader 1 (Compound 31) is a IKZF2 molecular glue degrader, with an DC50 of 0.5 nM. IKZF2-degrader 1 has minimal CK1α degradation activity relatively (DC50: 210 nM) . IKZF2-degrader 1 can be used for research of IKZF2-dependent cancers[1].
CAS Number
2983840-43-1
UNSPSC
12352211
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer
Smiles
CC(C)NC1=NNC2=C(CN3CCCC3)C=C(C4=C(F)C(CN(C5CCC(NC5=O)=O)C6=O)=C6C=C4)N=C21
Molecular Formula
C27H30FN7O3
Molecular Weight
519.57
References & Citations
[1]Zhang X, et al. Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders. Bioorg Med Chem Lett. 2025 May 5;124:130263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF2

Chemical Information

IKZF2-degrader 1
CAS Number2983840-43-1
PubChem CID169206423
IUPAC Name3-[7-fluoro-3-oxo-6-[3-(propan-2-ylamino)-7-(pyrrolidin-1-ylmethyl)-1H-pyrazolo[4,3-b]pyridin-5-yl]-1H-isoindol-2-yl]piperidine-2,6-dione
Molecular FormulaC27H30FN7O3
Molecular Weight519.6
XLogP2
Topological Polar Surface Area123
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count38
Formal Charge0
Complexity930
SMILES
CC(C)NC1=NNC2=C1N=C(C=C2CN3CCCC3)C4=C(C5=C(C=C4)C(=O)N(C5)C6CCC(=O)NC6=O)F
InChI
InChI=1S/C27H30FN7O3/c1-14(2)29-25-24-23(32-33-25)15(12-34-9-3-4-10-34)11-19(30-24)17-6-5-16-18(22(17)28)13-35(27(16)38)20-7-8-21(36)31-26(20)37/h5-6,11,14,20H,3-4,7-10,12-13H2,1-2H3,(H2,29,32,33)(H,31,36,37)
InChIKey
ZYMWJRANZLPARA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of IKZF2-degrader 1
CAS: 2983840-43-1
CID: 169206423
Formula: C27H30FN7O3
MW: 519.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight519.6
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass519.23941601
Monoisotopic Mass519.23941601
Topological Polar Surface Area123 Ų
Heavy Atom Count38
Formal Charge0
Complexity930
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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