Akt3 degrader 1

• UNSPSC Description:

  Akt3 degrader 1 (compound 12l) is a selective Akt3 degrader that overcomes Osimertinib (HY-15772)-induced resistance in H1975OR NSCLC cells. Akt3 degrader 1 also has anti-proliferative activity and significantly inhibits tumour growth in mice. Akt3 degrader 1 can be used in the study of drug-resistant non-small cell lung cancer[1].

• Target Antigen:

  Akt

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/akt3-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C=CC(N2CCN(CC2)CCCCCCCCCCCCNC(CC34CC5CC(C4)CC(C3)C5)=O)=C1)NC6=NC=C7C(C)=CC(N(C7=N6)C8=CC=CC(NC(C9CC9)=O)=C8)=O

• Molecular Weight:

  885.19

• References & Citations:

  [1]Xu F, et al. Discovery of Isoform-Selective Akt3 Degraders Overcoming Osimertinib-Induced Resistance in Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Oct 27;65(20):14032-14048.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2836342-69-7