DPP-1-IN-1

CAT: 0804-HY-174380Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174380Size:1 Each
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Description
DPP-1-IN-1 (Compound 14) is an orally active inhibitor of Cathepsin C (also known as Dipeptidyl peptidase I) with an IC50 of 5.31 nM. DPP-1-IN-1 can inhibit the activity of Cathepsin C downstream Neutrophil elastase in neutrophils. DPP-1-IN-1 can be used in the research of inflammatory diseases[1].
CAS Number
[2781135-27-9]
UNSPSC
12352005
Target
Dipeptidyl Peptidase; Elastase; Ser/Thr Protease
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(N[C@@H](CC1=C(F)C=C(C(C=CC(C#N)=C2)=C2CO3)C3=C1)C#N)[C@@H]4CNCCCO4
Molecular Formula
C23H21FN4O3
Molecular Weight
420.44
References & Citations
[1]Hao X, et al. Small molecule inhibitor of cathepsin c and medicinal use thereof. WO2022117059A1. 2022-06-09.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-1

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