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DPP

CAT: 0804-HY-155807Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155807Size:1 Each
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Description
DPP is a Platinum (IV) complex, bearing pterostilbene-derived axial ligand. DPP inhibit the JAK2-STAT3 pathway in breast cancer (BC) cells with antiproliferative activity, and activates caspase-3 and cleaved poly ADP-ribose polymerase to induces apoptosis. DPP promotes the maturation and antigen presentation of dendritic cells, and exhibits in vivo safety[1].
CAS Number
2668267-47-6
UNSPSC
12352005
Target
Apoptosis; JAK; STAT
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dpp.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=CC(/C=C/C(C=C2)=CC=C2OCC([O-][Pt+4]([Cl-])([Cl-])([NH3])([NH3])[O-]C(COC(C=C3)=CC=C3/C=C/C4=CC(OC)=CC(OC)=C4)=O)=O)=C1
Molecular Formula
C36H40Cl2N2O10Pt
Molecular Weight
926.70
References & Citations
[1]Cai L, et al. Platinum (IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. J Med Chem. 2023 Aug 24;66 (16) :11351-11364.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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