DPP

• Description:

  DPP is a Platinum (IV) complex, bearing pterostilbene-derived axial ligand. DPP inhibit the JAK2-STAT3 pathway in breast cancer (BC) cells with antiproliferative activity, and activates caspase-3 and cleaved poly ADP-ribose polymerase to induces apoptosis. DPP promotes the maturation and antigen presentation of dendritic cells, and exhibits in vivo safety[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; JAK; STAT

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dpp.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC (OC) =CC (/C=C/C (C=C2) =CC=C2OCC ([O-][Pt+4] ([Cl-]) ([Cl-]) ([NH3]) ([NH3]) [O-]C (COC (C=C3) =CC=C3/C=C/C4=CC (OC) =CC (OC) =C4) =O) =O) =C1

• Molecular Formula:

  C36H40Cl2N2O10Pt

• Molecular Weight:

  926.70

• References & Citations:

  [1]Cai L, et al. Platinum (IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. J Med Chem. 2023 Aug 24;66 (16) :11351-11364.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 3

• CAS Number:

  2668267-47-6