DPP IV/hCA II-IN-1

DPP IV/hCA II-IN-1

• CAS Number: 2836996-95-1
• UNSPSC Description: DPP IV/hCA II-IN-1 is a potent and selective dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA) inhibitor with an IC50 value of 0.049 μM for DPP IV and with Ki values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively[1].
• Target Antigen: Carbonic Anhydrase; Dipeptidyl Peptidase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/dpp-iv-hca-ii-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC(C1COC2=CC=CC=C2O1)CCOC3=CC=C(C=C3)S(=O)(N)=O
• Molecular Weight: 364.42
• References & Citations: [1]Artasensi A, et, al. Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101. J Med Chem. 2022 Oct 6.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported