DPP-4/GPR119 modulator 1

DPP-4/GPR119 modulator 1

• CAS Number: 2411099-68-6
• UNSPSC Description: DPP-4/GPR119 modulator 1 (Compound 22) is an orally active dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist. DPP-4/GPR119 modulator 1 shows blood glucose-lowering effect and moderate inhibition on hERG channel with an IC50 of 4.9 μM. DPP-4/GPR119 modulator 1 can be used for diabetes research[1][1]. DPP-4/GPR119 modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Dipeptidyl Peptidase; GPR119; Potassium Channel
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/dpp-4-gpr119-modulator-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC#CCN1C(N2CCC[C@H](C2)N)=NC3=C1C(N(C(N3C)=O)CCCN4CCN(CC4)C5=NC(C6=CC=CC=C6)=NO5)=O.Cl
• Molecular Weight: 623.15
• References & Citations: [1]Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported