DPP-21

CAT: 0931-MF-0142578-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0142578-01Size:25 mg
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CAS Number
2924883-83-8
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
DPP-21 is an inhibitor of microtubule protein polymerization (IC50: 2.4 ?M) . It exhibits antiproliferative activity against various cancer cell lines, with IC50 values of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23), and 9.37 nM (HepG2) . DPP-21 induces cell cycle arrest at the G2/M phase of mitosis and subsequently triggers apoptosis in tumor cells by decreasing Bcl-2 while increasing pro-apoptotic protein Bax levels.
Smiles
N1=C(N=C(C=2SC=CC12)N(C=3C=CC4=C(C=CN4C)C3)C)C
Molecular Formula
C17H16N4S
Molecular Weight
308.4
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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