RegisterLogin

DPP-21

CAT: 0804-HY-169096Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169096Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DPP-21 is an inhibitor of tubulin polymerization (IC50: 2.4 μM) . DPP-21 shows anti-proliferative activity against cancer cell lines, with IC50s of 0.38 nM (HCT116), 11.69 nM (B16), 5.37 nM (HeLa), 9.53 nM (MCF7), 8.94 nM (H23) and 9.37 nM (HepG2) respectively. DPP-21 arrests the cell cycle in the G2/M phase of mitosis, subsequently inducing tumor cell apoptosis (decreases Bcl-2 but upregulates the pro-apoptotic protein Bax) [1].
CAS Number
[2924883-83-8]
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dpp-21.html
Smiles
CC1=NC(N(C2=CC3=C(N(C=C3)C)C=C2)C)=C4SC=CC4=N1
Molecular Formula
C17H16N4S
Molecular Weight
308.40
References & Citations
[1]Xu C, et al. Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma. Eur J Med Chem. 2024 Nov 5;277:116791.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-155807DPP
HY-151384DPP-4-IN-2
HY-146455DPP-4-IN-3
HY-162513DPP-4-IN-10
HY-170800DPP-4-IN-15
HY-169110DPP-4-IN-12
HY-155027DPP-4-IN-8
HY-108319-01DPP-IV-IN-2
HY-159491DPP-4-IN-11
HY-157390DPP-4-IN-9

Alternative Products

CatalogName
T200560-01DPP-21
MBS5821270DPP
1964-5DPP IV Inhibitor, NVP DPP 728
OR1005110-01DPP-2Br
sc-133182Dpp (A-10)
GWB-566B54DPP substrate1
M26242-01DPP-IV-IN-2
JH917930DPP-C8C12-2Sn
JH915458DPP-C10C142-2Sn
T201436-01DPP-4-IN-13

Popular Products