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STING-IN-15

CAT: 0804-HY-173425-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173425-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STING-IN-15 (compound 66) is a potent STING inhibitor. STING-IN-15 inhibits human STING and mouse STING with IC50s of 116 and 96.3 nM, respectively. STING-IN-15 significantly alleviates tissue injury and inflammation in TREX1 D18N mouse model[1].
CAS Number
2912492-05-6
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Field of Research
Cancer; Inflammation/Immunology
Purity
99.04
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CNC2=C1C=C(C=C2)/C=C/CC#N)NC3=CC4=C(C=C3)OC(F)(F)O4
Molecular Formula
C20H14F2N4O3
Molecular Weight
396.35
References & Citations
[1]Shen A, et al. Discovery of Potent STING Inhibitors Bearing a Difluorobenzodioxol Structural Motif as Potent Anti-Inflammatory Agents. J Med Chem. 2025 Apr 24;68 (8) :8907-8932.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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