STING-IN-15

• Description:

  STING-IN-15 (compound 66) is a potent STING inhibitor. STING-IN-15 inhibits human STING and mouse STING with IC50s of 116 and 96.3 nM, respectively. STING-IN-15 significantly alleviates tissue injury and inflammation in TREX1 D18N mouse model[1].

• UNSPSC:

  12352005

• Target:

  STING

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Cancer; Inflammation/Immunology

• Purity:

  99.04

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (NC1=CNC2=C1C=C (C=C2) /C=C/CC#N) NC3=CC4=C (C=C3) OC (F) (F) O4

• Molecular Formula:

  C20H14F2N4O3

• Molecular Weight:

  396.35

• References & Citations:

  [1]Shen A, et al. Discovery of Potent STING Inhibitors Bearing a Difluorobenzodioxol Structural Motif as Potent Anti-Inflammatory Agents. J Med Chem. 2025 Apr 24;68 (8) :8907-8932.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2912492-05-6