STING-IN-15

• Description :

  STING-IN-15 (compound 66) is a potent STING inhibitor. STING-IN-15 inhibits human STING and mouse STING with IC50s of 116 and 96.3 nM, respectively. STING-IN-15 significantly alleviates tissue injury and inflammation in TREX1 D18N mouse model[1].

• CAS Number :

  [2912492-05-6]

• UNSPSC :

  12352005

• Target :

  STING

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer; Inflammation/Immunology

• Purity :

  99.04

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CNC2=C1C=C(C=C2)/C=C/CC#N)NC3=CC4=C(C=C3)OC(F)(F)O4

• Molecular Formula :

  C20H14F2N4O3

• Molecular Weight :

  396.35

• References & Citations :

  [1]Shen A, et al. Discovery of Potent STING Inhibitors Bearing a Difluorobenzodioxol Structural Motif as Potent Anti-Inflammatory Agents. J Med Chem. 2025 Apr 24;68 (8) :8907-8932.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported