STING-IN-16

CAT: 0931-T211330-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211330-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2982807-58-7

Target

Apoptosis, STING, ROS, Interleukin, IFNAR

Related Pathways

Apoptosis, Immunology/Inflammation

Bioactivity

STING-IN-16 is an inhibitor of STING, with an IC50 value of 44 nM in humans and 32 nM in mice. This compound effectively suppresses the activation of the STING pathway in both human and mouse cells. STING-IN-16 aids in restoring kidney mitochondrial function, inhibits the production of reactive oxygen species (ROS), and reduces apoptosis. It exhibits significant anti-inflammatory effects in vivo and is a valuable tool for researching autoimmune and autoinflammatory diseases.

Smiles

O=C(NC1=CNC=2C=CC(Cl)=CC21)N3CC4=CC=C(C=C4CC3)C=5C=CC(OC)=CC5

Molecular Formula

C25H22ClN3O2

Molecular Weight

431.91

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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