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STING-IN-8

CAT: 0804-HY-163749Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163749Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STING-IN-8 (Compound 15b) emerges as a potent stimulator of interferon gene (STING) inhibitor with an IC50 value of 0.121 μM in human and an IC50 value of 0.033 μM in mouse. STING-IN-8 inhibits MSA-2 or 2’, 3’ -cGAMP (HY-100564) -stimulated STING signaling and suppresses immune-inflammatory cytokine levels in both human and murine cells. STING-IN-8 is promising for research in the field of STING-associated inflammatory and autoimmune diseases[1].
UNSPSC
12352005
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sting-in-8.html
Smiles
CS(=O)(NC1=C(C=CC(NC(C2=NC(C3=CC=C(C=C3)OC(F)(F)F)=CS2)=O)=C1)O)=O
Molecular Formula
C18H14F3N3O5S2
Molecular Weight
473.45
References & Citations
[1]Jin Z, et al. Design, synthesis, and evaluation of thiazolecarboxamide derivatives as stimulator of interferon gene inhibitors[J]. Mol Divers. 2024 Apr 29, 1573-501X
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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