STING-IN-10

• Description :

  STING-IN-10 (P8) is a dual STING PROTAC degrader and inhibitor with a DC50 value of 2.58 μM in THP-1 cells. STING-IN-10 has anti-inflammatory activity[1]. (Pink: Target protein ligand (HY-168676) ; Black: linker (HY-W123015) ; Blue: E3 ligase ligand (HY-126457) )

• UNSPSC :

  12352211

• Target :

  PROTACs; STING

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; PROTAC

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/sting-in-10.html

• Smiles :

  O=C1CCC(C(N1)=O)N2C(C3=CC=CC(OCC4=CN(N=N4)CCCCCC(OCCC5=CC=C(C=C5)NC(C6=CC=C(O6)[N+]([O-])=O)=O)=O)=C3C2=O)=O

• Molecular Formula :

  C35H33N7O11

• Molecular Weight :

  727.68

• References & Citations :

  [1]Xue L, Liu R, Zhang L, Qiu T, Liu L, Yin R, Jiang T. Discovery of novel nitrofuran PROTAC-like compounds as dual inhibitors and degraders targeting STING. Eur J Med Chem. 2024 Dec 5;279:116883.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported