STING-IN-10

• UNSPSC Description:

  STING-IN-10 (P8) is a dual STING PROTAC degrader and inhibitor with a DC50 value of 2.58 μM in THP-1 cells. STING-IN-10 has anti-inflammatory activity[1].(Pink: Target protein ligand (HY-168676); Black: linker (HY-W123015); Blue: E3 ligase ligand (HY-126457))

• Target Antigen:

  PROTACs; STING

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/sting-in-10.html

• Smiles:

  O=C1CCC(C(N1)=O)N2C(C3=CC=CC(OCC4=CN(N=N4)CCCCCC(OCCC5=CC=C(C=C5)NC(C6=CC=C(O6)[N+]([O-])=O)=O)=O)=C3C2=O)=O

• Molecular Weight:

  727.68

• References & Citations:

  [1]Xue L, Liu R, Zhang L, Qiu T, Liu L, Yin R, Jiang T. Discovery of novel nitrofuran PROTAC-like compounds as dual inhibitors and degraders targeting STING. Eur J Med Chem. 2024 Dec 5;279:116883.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported