STING-IN-16

• Description:

  STING-IN-16 is a STING inhibitor with IC50 values of 44 nM (human) and 32 nM (mice) for cellular STING inhibition. STING-IN-16 effectively inhibits the activation of the STING axis in both human and murine cells. STING-IN-16 can restore renal mitochondrial function, suppress reactive oxygen species (ROS) production, and reduce cell apoptosis. STING-IN-16 shows robust anti-inflammatory efiicacy in vivo. STING-IN-16 can be used for the study of autoimmune and autoinflammatory diseases[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; IFNAR; Interleukin Related; Reactive Oxygen Species (ROS) ; STING

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(N1CCC2=C(C1)C=CC(C3=CC=C(C=C3)OC)=C2)NC4=CNC5=C4C=C(C=C5)Cl

• Molecular Formula:

  C25H22ClN3O2

• Molecular Weight:

  431.91

• References & Citations:

  [1]Zhou X, et al. Discovery of 3,4-dihydroisoquinoline-2 (1H) -carboxamide STING inhibitors as anti-inflammatory agents. Eur J Med Chem. 2025 Jul 1;297:117922.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2982807-58-7