STING-IN-16

CAT: 0804-HY-175210Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175210Size:1 Each
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Description
STING-IN-16 is a STING inhibitor with IC50 values of 44 nM (human) and 32 nM (mice) for cellular STING inhibition. STING-IN-16 effectively inhibits the activation of the STING axis in both human and murine cells. STING-IN-16 can restore renal mitochondrial function, suppress reactive oxygen species (ROS) production, and reduce cell apoptosis. STING-IN-16 shows robust anti-inflammatory efiicacy in vivo. STING-IN-16 can be used for the study of autoimmune and autoinflammatory diseases[1].
CAS Number
[2982807-58-7]
UNSPSC
12352005
Target
Apoptosis; IFNAR; Interleukin Related; Reactive Oxygen Species (ROS) ; STING
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(N1CCC2=C(C1)C=CC(C3=CC=C(C=C3)OC)=C2)NC4=CNC5=C4C=C(C=C5)Cl
Molecular Formula
C25H22ClN3O2
Molecular Weight
431.91
References & Citations
[1]Zhou X, et al. Discovery of 3,4-dihydroisoquinoline-2 (1H) -carboxamide STING inhibitors as anti-inflammatory agents. Eur J Med Chem. 2025 Jul 1;297:117922.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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