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Methylene Blue

CAT: 0804-HY-14536-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14536-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene Blue is a photosensitizer and redox agent. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation[1][2][3][4].
CAS Number
61-73-4
Product Name Alternative
Basic Blue 9; CI-52015; Methylthioninium (chloride)
UNSPSC
12171500
Hazard Statement
H302, H315, H319, H335
Target
Guanylate Cyclase; Microtubule/Tubulin; Monoamine Oxidase; NO Synthase
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Methylene-Blue.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
CN(C)C1=CC=C2C(SC(C(C=C/3)=N2)=CC3=[N+](C)/C)=C1.[Cl-]
Molecular Formula
C16H18ClN3S
Molecular Weight
319.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Klamer D, et, al. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol. 2004 Feb;94 (2) :65-72. |[2]Hochgräfe K, et, al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015 May 10;3:25.|[3]Fenn AM, et, al. Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. J Neurotrauma. 2015 Jan 15;32 (2) :127-38.|[4]Kalaitzakis D, et al. Methylene Blue as a Photosensitizer and Redox Agent: Synthesis of 5-Hydroxy-1H-pyrrol-2 (5H) -ones from Furans. Angew Chem Int Ed Engl. 2015 May 18;54 (21) :6283-7.
Shipping Conditions
Room Temperature
Storage Conditions
RT, sealed storage, away from moisture and light
Scientific Category
Dye Reagents
Clinical Information
Launched
Citation 01
Bioengineering (Basel) . 2025 Oct 27;12 (11) :1164.|Biomaterials. 2023 Feb:293:121988.|Biomed Res Int. 2021 May 14:2021:5565748.|Cell Rep. 2024 Feb 13;43 (2) :113779.|Cell Rep. 2025 Nov 25;44 (11) :116520.|Chem Eng J. 2025 Nov 24;526:171230.|Curr Res Virol Sci. 2022;3:100019.|Evid Based Complement Alternat Med. 2020 Mar 10;2020:3524641.|Exp Ther Med. 2019 Nov;18 (5) :4049-4057.|Hematology. 2022 Dec;27 (1) :43-52.|J Nanobiotechnology. 2025 Jul 4;23 (1) :485.|Nat Commun. 2024 Nov 27;15 (1) :10303.|Patent. US20230226111A1.|Patent. US20240238271A1.|Patent. US20240325538A1.|Phytomedicine. 2025 Oct 20:148:157423.|Phytother Res. 2023 Apr;37 (4) :1405-1421.|Redox Biol. 2020 Sep;36:101601.|Research Square Print. 2023 Feb 21.|Theranostics. 2021 Oct 17;11 (20) :9884-9903.|World J Gastrointest Surg. 2023 Jun 27;15 (6) :1068-1079.|BMC Cancer. 2024 Dec 3;24 (1) :1489.|Cell Signal. 2025 Sep 18:136:112145.|Res Sq. 2025 Nov 12.

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