STING-IN-14

• Description:

  STING-IN-14 is an inhibitor of STING (IC50: 0.6 nM) . STING-IN-14 inhibits the activation of the IRF pathway in THP1-DualTM cells. STING-IN-14 can be used in autoimmune diseases research[1].

• UNSPSC:

  12352005

• Target:

  STING

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  [H][C@]1(C(NC[C@@H](C(NCC2=CC=CC=C2)=O)NC([C@]3([H])C[C@@](O4)([H])CN3C5=NC=NC6=C5C=NN6C7=C(F)C=C(F)C=C7)=O)=O)N(CCN8N=C(C=CC=C9C%10=CC=CC4=C%10)C9=C8)CCOC1

• Molecular Formula:

  C46H43F2N11O5

• Molecular Weight:

  867.90

• References & Citations:

  [1]1. Han X, et al. Macrocycles for the treatment of autoimmune disease and their preparation. WO2025021666. F. Hoffmann-La Roche AG, Switzerland. 2025-01-30.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3070953-78-2]