ASK1-IN-8

• Description:

  ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM[1]. In an experimental mouse model of liver injury induced by Acetaminophen (HY-66005), ASK1-IN-8 can significantly reduce the plasma alanine transaminase (ALT) level, protecting the liver[1]. ASK1-IN-8 can be used in research related to liver diseases[1].

• UNSPSC:

  12352005

• Target:

  ASK1

• Related Pathways:

  Apoptosis

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CNC (C1CCN (C2=CC=C (N3C (N (C4=NC (C5=NN=CN5C (C) C) =CC=C4) CC3) =O) C=C2) CC1) =O

• Molecular Formula:

  C26H32N8O2

• Molecular Weight:

  488.58

• References & Citations:

  [1]Rai SK, et al. Identification and evaluation of cyclic urea based 4H-triazolo pyridine substituted derivatives as novel ASK1 inhibitors. Bioorg Chem. 2025 Mar 14;159:108375.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2570985-89-4