ASK1-IN-8

• Description :

  ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM[1]. In an experimental mouse model of liver injury induced by Acetaminophen (HY-66005), ASK1-IN-8 can significantly reduce the plasma alanine transaminase (ALT) level, protecting the liver[1]. ASK1-IN-8 can be used in research related to liver diseases[1].

• UNSPSC :

  12352005

• Target :

  ASK1

• Related Pathways :

  Apoptosis

• Field of Research :

  Inflammation/Immunology

• Smiles :

  CNC(C1CCN(C2=CC=C(N3C(N(C4=NC(C5=NN=CN5C(C)C)=CC=C4)CC3)=O)C=C2)CC1)=O

• Molecular Formula :

  C26H32N8O2

• Molecular Weight :

  488.58

• References & Citations :

  [1]Rai SK, et al. Identification and evaluation of cyclic urea based 4H-triazolo pyridine substituted derivatives as novel ASK1 inhibitors. Bioorg Chem. 2025 Mar 14;159:108375.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2570985-89-4]