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FR167344 free base

CAT: 0804-HY-100301Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100301Size:1 Each
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Description
FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC50 value of 65 nM and no binding affinity for the B1 receptor.
CAS Number
215258-13-2
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bradykinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/FR167344_free_base.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C)C)C1=CC=C(/C=C/C(NCC(N(C2=CC=C(Cl)C(COC3=CC=CN4C3=NC(C)=C4Br)=C2Cl)C)=O)=O)C=C1
Molecular Formula
C30H28BrCl2N5O4
Molecular Weight
673.38
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Aramori I, et al. Novel subtype-selective nonpeptide bradykinin receptor antagonists FR167344 and FR173657. Mol Pharmacol. 1997 Feb;51 (2) :171-6.|[2]Asano M, et al. Effects of a nonpeptide bradykinin B2 receptor antagonist, FR167344, on different in vivoanimal models of inflammation.Br J Pharmacol. 1997 Dec;122 (7) :1436-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bradykinin B2 Receptor (B2R)

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