ASK1-IN-1

• UNSPSC Description:

  ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)[1].

• Target Antigen:

  MAP3K; p38 MAPK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ask1-in-1-1.html

• Smiles:

  COC1=NN(C2=NC=CN=C2)C=C1C(NC3=NC(C4=NN=CN4C(C)C)=CC=C3)=O

• Molecular Weight:

  405.41

• References & Citations:

  [1]Xin Z, et al. Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors. ACS Med Chem Lett. 2020;11(4):485-490. Published 2020 Feb 12.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2411382-24-4