ASK1-IN-6

• Target:

  MAPK

• Related Pathways:

  MAPK

• Bioactivity:

  ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp, uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.

• Smiles:

  [C@@H](C(F)(F)F)(C)N1C(=NN=C1)C=2N=C(NC(=O)C3=C(OC)N=CC(F)=C3)C=CC2

• Molecular Formula:

  C17H14F4N6O2

• Molecular Weight:

  410.33

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2407451-82-3