ASK1-IN-6

CAT: 0931-T88037-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T88037-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2407451-82-3
Target
MAPK
Related Pathways
MAPK
Bioactivity
ASK1-IN-6 (Compound 32), a selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor, exhibits an IC50 of 25 nM. This compound readily crosses the blood-brain barrier, as evidenced by rat pharmacokinetics showing a clearance/unchanged clearance rate of 1.6/56 L/h/kg and an unbound partition coefficient (Kp, uu) of 0.46. Additionally, ASK1-IN-6 demonstrates anti-inflammatory activity and effectively improves symptoms in the Alzheimer's Disease Tg4510 mouse model.
Smiles
[C@@H](C(F)(F)F)(C)N1C(=NN=C1)C=2N=C(NC(=O)C3=C(OC)N=CC(F)=C3)C=CC2
Molecular Formula
C17H14F4N6O2
Molecular Weight
410.33
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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