ASK1-IN-8

• Target:

  ASK

• Related Pathways:

  Apoptosis

• Bioactivity:

  ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.

• Smiles:

  O=C1N (C2=NC (=CC=C2) C3=NN=CN3C (C) C) CCN1C4=CC=C (C=C4) N5CCC (C (=O) NC) CC5

• Molecular Formula:

  C26H32N8O2

• Molecular Weight:

  488.585

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2570985-89-4