ASK1-IN-4

• Description :

  ASK1-IN-4 (Compound 17) is an ASK1 inhibitor (IC50=0.2 μM) . ASK1-IN-4 interacts with ATP-binding site of ASK1[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; ASK1; MAP3K

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ask1-in-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  BrC(C=C1)=CC=C1C2=CC=C(O2)/C=C3C(N(C(S/3)=S)CCCC(O)=O)=O

• Molecular Formula :

  C18H14BrNO4S2

• Molecular Weight :

  452.34

• References & Citations :

  [1]Starosyla SA, et al. ASK1 pharmacophore model derived from diverse classes of inhibitors. Bioorg Med Chem Lett. 2014 Sep 15;24 (18) :4418-4423.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAP3K5/ASK1

• CAS Number :

  [1427538-26-8]