ASK1-IN-12

• Description:

  ASK1-IN-12 is an ASK1 inhibitor with an IC50 of 6.3 nM. ASK1-IN-12 inhibits TNF-α-induced activation of the ASK1-p38/JNK pathway. ASK1-IN-12 can reduce free fatty acid-induced cholesterol increase, lipid droplet accumulation and improves hepatocellular steatosis. ASK1-IN-12 can be used for the research of non-alcoholic steatohepatitis (NASH) [1].

• UNSPSC:

  12352005

• Target:

  ASK1; JNK; p38 MAPK

• Related Pathways:

  Apoptosis; MAPK/ERK Pathway

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Smiles:

  O=C(NC1=CC=CC(C2=NN=CN2[C@H](C(F)(F)F)C)=N1)C3=NN4C=CC(C5=CN(C(C)C)N=C5)=CC4=C3

• Molecular Formula:

  C24H22F3N9O

• Molecular Weight:

  509.49

• References & Citations:

  [1]Liu H, et al. Pyrazolopyridine derivatives as potent ASK1 inhibitors: design, synthesis, and biological evaluation. Bioorg Chem. 2025;167:109176.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported