ASK1-IN-2

• Description :

  ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; ASK1; MAP3K

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ask1-in-2.html

• Concentration :

  10mM

• Purity :

  99.55

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O=C(C(N1)=CC2=C1C=C(F)C=C2)NC3=NC(C4=NN=CN4C(C)C)=CC=C3

• Molecular Formula :

  C19H17FN6O

• Molecular Weight :

  364.38

• References & Citations :

  [1]Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAP3K5/ASK1

• CAS Number :

  [2541792-70-3]