ASK1-IN-3

• Description :

  ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; ASK1; MAP3K

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; MAPK/ERK Pathway

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/ask1-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C[C@@H](N1C=NN=C1C2=NC(NC(NC3=NN4C=CC=CC4=C3)=O)=CC=C2)CO

• Molecular Formula :

  C18H18N8O2

• Molecular Weight :

  378.39

• References & Citations :

  [1]Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1) . Eur J Med Chem. 2020;195:112277.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MAP3K5/ASK1

• CAS Number :

  [2426705-19-1]