ASK1-IN-3

• UNSPSC Description:

  ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].

• Target Antigen:

  Apoptosis; MAP3K

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ask1-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@H](N1C=NN=C1C2=NC(NC(NC3=NN4C=CC=CC4=C3)=O)=CC=C2)CO

• Molecular Weight:

  378.39

• References & Citations:

  [1]Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem. 2020;195:112277.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2426705-19-1