ASK1-IN-3
CAT:
804-HY-146729
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ASK1-IN-3
- CAS Number: 2426705-19-1
- UNSPSC Description: ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1].
- Target Antigen: Apoptosis; MAP3K
- Type: Reference compound
- Related Pathways: Apoptosis;MAPK/ERK Pathway
- Applications: COVID-19-immunoregulation
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/ask1-in-3.html
- Solubility: 10 mM in DMSO
- Smiles: C[C@@H](N1C=NN=C1C2=NC(NC(NC3=NN4C=CC=CC4=C3)=O)=CC=C2)CO
- Molecular Weight: 378.39
- References & Citations: [1]Zhang S, Huang C, Lyu X, et al. Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). Eur J Med Chem. 2020;195:112277.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported