ASK1-IN-6
CAT:
804-HY-160939-01
Size:
5 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ASK1-IN-6
- CAS Number: 2407451-82-3
- UNSPSC Description: ASK1-IN-6 (Compound 32) is a selective inhibitor for apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 25 nM. ASK1-IN-6 is blood brain barrier penetrate(rat Cl/Clu is 1.6/56 L/h/kg and Kp,uu is 0.46). ASK1-IN-6 exhibits anti-inflammatory avtivity and ameliorates the Alzheimer’s Disease in Tg4510 mouse model[1].
- Target Antigen: MAP3K
- Type: Reference compound
- Related Pathways: MAPK/ERK Pathway
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/ask1-in-6.html
- Smiles: FC(F)(F)[C@@H](N1C(C2=CC=CC(NC(C3=C(N=CC(F)=C3)OC)=O)=N2)=NN=C1)C
- Molecular Weight: 410.33
- References & Citations: [1]Jones JH, et al., Discovery of Potent, Selective, and Brain-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors that Modulate Brain Inflammation In Vivo. J Med Chem. 2021 Oct 28;64(20):15402-15419.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported