PPARγ-IN-2

• UNSPSC Description:

  PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue[1].

• Target Antigen:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pparγ-in-2.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=CC1=C(C2=NC=CC(NCCN3CCCC3)=N2)NC4=CC=CC=C14

• Molecular Weight:

  335.40

• References & Citations:

  [1]Guo SY, et al. Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism. Eur J Med Chem. 2023 Nov 15;260:115729.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2682078-97-1