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γ-Secretase modulator 4

CAT: 0804-HY-128581-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128581-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.014 μM and 0.017 μM in human and mouse, respectively[1].
CAS Number
1420200-82-3
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gamma-secretase-modulator-4.html
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(OC)C2=C(C=C1)NC(C3=CN(CCO[C@H]4C5=CC=CC(F)=C5C)C4=N3)=C2
Molecular Formula
C23H19FN4O2
Molecular Weight
402.42
References & Citations
[1]Bischoff FP, et al. Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators. Bioorg Med Chem Lett. 2019 Jul 15;29 (14) :1737-1745.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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