BJP-07-017-3

• Description:

  BJP-07-017-3 is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 9 nM. BJP-07-017-3 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation[1].

• UNSPSC:

  12352005

• Target:

  PIN1

• Related Pathways:

  PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Smiles:

  CN (C (CCl) =O) [C@H] (C (N1CCCC[C@H]1C (N[C@H] (C (N[C@@H] (CCCNC (N) =O) C (N) =O) =O) CC2=CNC3=C2C=CC=C3) =O) =O) CC4=CC=CC=C4

• Molecular Formula:

  C35H45ClN8O6

• Molecular Weight:

  709.23

• References & Citations:

  [1]Alboreggia G, et al., Targeted degradation of Pin1 by protein-destabilizing compounds. Proc Natl Acad Sci U S A. 2024 Nov 19;121 (47) :e2403330121.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2468783-22-2