SL-017

CAT: 0804-HY-121642Size: 1 EachDry Ice: NoHazardous: No

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Description

SL-017 is a novel photoacoustic sensitizer and a derivative of photofrin B. It can be taken up by cells to the maximum extent within 30 minutes and is mainly localized in mitochondria. After being activated by visible light or ultrasound, SL-017 can significantly increase the production of reactive oxygen species (ROS) . Low concentrations of SL-017 can rapidly cause the loss of mitochondrial membrane potential. SL-017 can also cause mitochondrial fragmentation, a process that occurs after the loss of membrane potential. Epoxyeicosatrienoic acids (EETs) can alleviate the loss of mitochondrial membrane potential caused by SL-017, but the antioxidant ascorbic acid has no such effect. These characteristics indicate that SL-017 mainly targets mitochondria and exerts its cytotoxic effect by triggering the collapse of mitochondrial membrane potential, generating ROS, and causing mitochondrial fragmentation. As a novel photoacoustic sensitizer, SL-017 has potential application value in photodynamic therapy and sonodynamic therapy.

CAS Number

1169831-01-9

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/sl-017.html

Smiles

COC1=C2C3=C4C(C5=C(O)C(NCCCN(C)C)=C4C=C(C)C2C(C)=O)=C(C(OC)=CC5=O)C6=C3C(C(C=C6OC)=O)=C1O

Molecular Formula

C34H34N2O8

Molecular Weight

598.64

References & Citations

[1]Sonodynamic and photodynamic mechanisms of action of the novel hypocrellin sonosensitizer, SL017: mitochondrial cell death is attenuated by 11, 12-epoxyeicosatrienoic acid

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

1H-Cyclohepta[ghi]perylene-6,11-dione, 1-acetyl-4-[[3-(dimethylamino)propyl]amino]-5,12-dihydroxy-8,9,13-trimethoxy-2-methyl-

CAS Number	1169831-01-9
PubChem CID	15942635
IUPAC Name	14-acetyl-10-[3-(dimethylamino)propylamino]-9,17-dihydroxy-5,16,21-trimethoxy-13-methylhexacyclo[13.8.0.02,11.03,8.04,22.018,23]tricosa-1(15),2(11),3(8),4(22),5,9,12,16,18(23),20-decaene-7,19-dione
Molecular Formula	C34H34N2O8
Molecular Weight	598.6
XLogP	4.7
Topological Polar Surface Area	135
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Heavy Atom Count	44
Formal Charge	0
Complexity	1290

SMILES

CC1=CC2=C3C4=C(C1C(=O)C)C(=C(C5=C4C(=C6C3=C(C(=O)C=C6OC)C(=C2NCCCN(C)C)O)C(=CC5=O)OC)O)OC

InChI

InChI=1S/C34H34N2O8/c1-14-11-16-22-27-23(32(40)31(16)35-9-8-10-36(3)4)17(38)12-19(42-5)25(27)26-20(43-6)13-18(39)24-29(26)28(22)30(21(14)15(2)37)34(44-7)33(24)41/h11-13,21,35,40-41H,8-10H2,1-7H3

InChIKey

HVFLCVDBQRVGTE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1169831-01-9

CID: 15942635

Formula: C34H34N2O8

MW: 598.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	598.6
XLogP3	4.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Exact Mass	598.23151605
Monoisotopic Mass	598.23151605
Topological Polar Surface Area	135 Å²
Heavy Atom Count	44
Formal Charge	0
Complexity	1290
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-W419140-01	AND-017
HY-174212	MXC-017
HY-18051	CXL 017
HY-147082-01	GA-017
HY-P1338	PL-017
HY-19291	DL-017
HY-118821	JTC-017
HY-106972	SL-251131
HY-19873	SL-052
HY-172609-01	SL-176

Alternative Products

Catalog	Name
MBS5784158	SL-017
GTR19281005-01	AND-017
T210882-01	MXC-017
T24216-01	JTC-017
M30590-01	PL 017
C01502-10mM/1mL	GA-017
TP1958	PL-017

SL-017

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