GA-017

• Description :

  GA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids[1].

• UNSPSC :

  12352005

• Target :

  YAP

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ga-017.html

• Concentration :

  10mM

• Purity :

  98.95

• Solubility :

  DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles :

  O=C(NCC1=CC(O)=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O

• Molecular Formula :

  C18H21N3O4

• Molecular Weight :

  343.38

• References & Citations :

  [1]Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298 (4) :101779.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  YAP/TAZ

• CAS Number :

  [2351906-74-4]