CXL 017

CAT: 0804-HY-18051Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18051Size:1 Each
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Description
CXL 017 is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor. CXL 017 can inhibit the ATPase activity of SERCA by competing with ATP for binding. CXL 017 exhibits selective cytotoxicity against multidrug-resistant acute myeloid leukemia cells HL60/MX2. CXL 017 can be used in the research of tumors such as multidrug-resistant acute myeloid leukemia[1].
CAS Number
[1063714-11-3]
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=C(N)OC2=C(C=C(C3=CC(OC)=CC(OC)=C3)C=C2)C1CC(OCC)=O)OCC
Molecular Formula
C24H27NO7
Molecular Weight
441.47
References & Citations
[1]Bleeker NP, et al. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Mol Pharm. 2013 Nov 4;10 (11) :4358-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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