CXL 017

• Description:

  CXL 017 is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor. CXL 017 can inhibit the ATPase activity of SERCA by competing with ATP for binding. CXL 017 exhibits selective cytotoxicity against multidrug-resistant acute myeloid leukemia cells HL60/MX2. CXL 017 can be used in the research of tumors such as multidrug-resistant acute myeloid leukemia[1].

• UNSPSC:

  12352005

• Target:

  Calcium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C (C1=C (N) OC2=C (C=C (C3=CC (OC) =CC (OC) =C3) C=C2) C1CC (OCC) =O) OCC

• Molecular Formula:

  C24H27NO7

• Molecular Weight:

  441.47

• References & Citations:

  [1]Bleeker NP, et al. A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML. Mol Pharm. 2013 Nov 4;10 (11) :4358-66.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1063714-11-3