MXC-017

CAT: 0931-T210882-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T210882-01Size:10 mg
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CAS Number
3037024-97-5
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
MXC-017 is an apoptosis inducer capable of crossing the blood-brain barrier, specifically targeting glioma stem cells (GSCs) . It effectively prevents the formation of radiation-induced GSCs while promoting G0/G1 cell cycle arrest and apoptosis. With minimal off-target effects, MXC-017 exhibits no significant cytotoxicity even at concentrations up to 10 µM. Additionally, it significantly extends the median survival in patient-derived orthotopic xenograft (PDOX) glioblastoma (GBM) mouse models when used in conjunction with radiation therapy.
Smiles
O=C(NCC1=CC=C(C=C1)S(=O)(=O)N2CCCCC2)N3C=CC=4C=CC=CC43
Molecular Formula
C21H23N3O3S
Molecular Weight
397.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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