MXC-017

• Description:

  MXC-017 is a blood-brain barrier (BBB) -penetrant apoptosis inducer that directly targets Vimentin (VIM) . MXC-017 prevents radiation-induced glioma stem cell (GSC) formation, while promoting G0/G1 cell cycle arrest and apoptosis. MXC-017 exhibits minimal off-target effects and shows no significant cytotoxicity. MXC-017 significantly prolongs median survival when used in combination with radiation therapy in glioblastoma (GBM) mouse models.

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Smiles:

  O=C (NCC1=CC=C (S (=O) (N2CCCCC2) =O) C=C1) N3C4=CC=CC=C4C=C3

• Molecular Formula:

  C21H23N3O3S

• Molecular Weight:

  397.49

• References & Citations:

  [1]He L, et al. Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma[J]. bioRxiv, 2025: 2025.04. 10.648292.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3037024-97-5