MXC-017

• Description :

  MXC-017 is a blood-brain barrier (BBB) -penetrant apoptosis inducer that directly targets Vimentin (VIM) . MXC-017 prevents radiation-induced glioma stem cell (GSC) formation, while promoting G0/G1 cell cycle arrest and apoptosis. MXC-017 exhibits minimal off-target effects and shows no significant cytotoxicity. MXC-017 significantly prolongs median survival when used in combination with radiation therapy in glioblastoma (GBM) mouse models.

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer

• Smiles :

  O=C(NCC1=CC=C(S(=O)(N2CCCCC2)=O)C=C1)N3C4=CC=CC=C4C=C3

• Molecular Formula :

  C21H23N3O3S

• Molecular Weight :

  397.49

• References & Citations :

  [1]He L, et al. Design and Biological Activity of a Novel Brain Penetrant Urea Compound Against Glioblastoma[J]. bioRxiv, 2025: 2025.04. 10.648292.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3037024-97-5]