JTC-017

• Description :

  JTC-017, a specific corticotropin-releasing hormone receptor 1 antagonist, attenuates hippocampal noradrenaline release, visceral perception, adrenocorticotropic hormone release, and anxiety after acute colorectal distention in rats. JTC-017 blocks stress-induced changes in colonic motility after chronic colorectal distention in rats[1].

• UNSPSC :

  12352005

• Target :

  CRFR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/jtc-017.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC(Cl)=C(C(Cl)=C1)O)NC2=CC(S(=O)(N(CC)CC)=O)=CC(N(C)C)=C2OC

• Molecular Formula :

  C20H25Cl2N3O5S

• Molecular Weight :

  490.40

• References & Citations :

  [1]Saito K, et al. Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats. Gastroenterology. 2005;129 (5) :1533-1543.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [357330-77-9]