PDE4-IN-18

• Target:

  Interleukin|||PDE|||TNF

• Related Pathways:

  Metabolism|||Immunology/Inflammation|||Apoptosis

• Bioactivity:

  PDE4-IN-18 (compound 1l) is a PDE4 inhibitor with an IC50 value of 1.55 ?M and exhibits anti-inflammatory activity. It mitigates inflammation by reducing excessive infiltration of immune cells and enthesial formation, as well as decreasing the mRNA expression of pro-inflammatory cytokines (such as TNF-? and IL-6) in the synovial tissues. PDE4-IN-18 is suitable for research into rheumatoid arthritis and psoriasis.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C