PDE4-IN-18

PDE4-IN-18

• UNSPSC Description: PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis[1].
• Target Antigen: Interleukin Related; Phosphodiesterase (PDE); TNF Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde4-in-18.html
• Smiles: O=C1C2=CC(F)=CC=C2C(CC=C)=C(C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CC=C3)N1
• Molecular Weight: 434.48
• References & Citations: [1]Bhuktar, et al. "Targeting next-generation PDE4 inhibitors in search of potential management of rheumatoid arthritis and psoriasis." Bioorganic Chemistry (2024): 107689.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported