Products for Research Use Only
RegisterLogin

PDE4-IN-18

CAT: 0804-HY-162797Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-162797Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis[1].
UNSPSC
12352211
Target
Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-18.html
Smiles
O=C1C2=CC(F)=CC=C2C(CC=C)=C(C3=CC(NS(=O)(C4=CC=CC=C4)=O)=CC=C3)N1
Molecular Formula
C24H19FN2O3S
Molecular Weight
434.48
References & Citations
[1]Bhuktar, et al. "Targeting next-generation PDE4 inhibitors in search of potential management of rheumatoid arthritis and psoriasis." Bioorganic Chemistry (2024) : 107689.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

Related Products

CatalogName
HY-144684PDE4-IN-8
HY-155692PDE4-IN-13
HY-159654PDE4-IN-19
HY-169981PDE4-IN-24
HY-162583PDE4-IN-17
HY-132887PDE4-IN-3
HY-151174PDE4-IN-12
HY-161381PDE4-IN-15
HY-115871PDE4-IN-4
HY-179639PDE4-IN-30

Alternative Products

CatalogName
T89424-01PDE4-IN-18
BA8215-10PDE4-IN-14
T211159-01PDE4-IN-29
T210960-01PDE4-IN-28
T210238-01PDE4-IN-17
T200132-01PDE4-IN-19
T62969-01PDE4-IN-6
T60934-01PDE4-IN-9
T63912-01PDE4-IN-12
T50023-01PDE4-IN-20

Popular Products