ABP/PPAR modulator 1

• Target :

  FABP|||PPAR

• Related Pathways :

  DNA Damage/DNA Repair|||Metabolism

• Bioactivity :

  ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 ?M for FABP1 and 1.08 ?M for FABP4, and EC50 values of 9.19 ?M, 2.20 ?M, and 1.58 ?M for PPAR?, PPAR?, and PPAR?, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH) . Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.

• Smiles :

  COC1=CC=C(/C=C/C2=CC(OC)=CC(OCC3=CC=C(OC(C(N[C@@H](C(O)=O)CC(C)C)=O)(C)C)C=C3)=C2)C=C1

• Molecular Formula :

  C33H39NO7

• Molecular Weight :

  561.67

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C