PLK1/BRD4-IN-3

CAT: 0931-T87990-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T87990-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2251709-91-6

Target

PLK, Epigenetic Reader Domain

Related Pathways

Cell Cycle/Checkpoint, Chromatin/Epigenetic

Bioactivity

Compound 21, also known as PLK1/BRD4-IN-3, acts as a selective dual inhibitor targeting both bromodomain 4 (BRD4) and polo-like kinase 1 (PLK1) . It effectively inhibits BRD4-BD1, PLK1, and BRDT-BD1, exhibiting IC50 values of 0.059, 0.127, and 0.245 μM, respectively.

Smiles

C[C@@H]1N(C=2C(=CN=C(NC3=C(OC4CCCC4)C=C(C(NC5CCN(C)CC5)=O)C=C3)N2)N(C)C1=O)C6CCCC6

Molecular Formula

C31H43N7O3

Molecular Weight

561.72

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Related Products

Catalog	Name
T87220-01	PLK1/BRD4-IN-2
T64058-01	PLK1/BRD4-IN-1
T209444-01	PLK1/BRD4-IN-5
T30580-01	BRD4-Kinases-IN-3
T209282-01	BRD4-BD1-IN-3
T200653-01	PARP1/BRD4-IN-3
T89841-01	PROTAC BRD4 ligand-3
T13835-01	PROTAC BRD4 Degrader-3
T210452-01	BRD4-BD1/2-IN-3
T18598-01	PROTAC BRD2/BRD4 degrader-1

Alternative Products

Catalog	Name
HY-160558-01	PLK1/BRD4-IN-3
HY-160557-01	PLK1/BRD4-IN-2
GTR19185523-01	PLK1/BRD4-IN-1
HY-158031-01	PLK1/BRD4-IN-5
HY-104072	BRD4-IN-3
HY-169170	PARP1/BRD4-IN-3
MBS5780213	BRD4-Kinases-IN-3
HY-136857-01	BRD4 degrader-3
GTR19261923-01	BRD4-BD1-IN-3
GTR19274866-01	BRD4 D1-IN-3

PLK1/BRD4-IN-3

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