ALK5 Extracellular Domain Human Recombinant

• Description:

  ALK5 Extracellular Domain Human Recombinant _x000D_ Catalog number: B2016873_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 38.1 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Activin Receptor-like Kinase 5, Serine/threonine Protein Kinase Receptor 4, SKR4, TGF-βRI, Transforming Growth Factor β Receptor Type I_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Zhang Y, Zhang J, Navrazhina K, Argaw AT, Zameer A, Gurfein BT, Brosnan CF, John GR. TGFbeta1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation Glia. 2010 Jun;58(8):964-74._x000D_ 2: Sridharan S, Nagarajan SK, Venugopal K, Venkatasubbu GD. Time-dependent conformational analysis of ALK5-lumican complex in presence of graphene and graphene oxide employing molecular dynamics and MMPBSA calculation J Biomol Struct Dyn. 2022 Aug;40(13):5932-5955._x000D_ 3: Pitou M, Papachristou E, Bratsios D, Kefala GM, Tsagkarakou AS, Leonidas DD, Aggeli A, Papadopoulos GE, Papi RM, Choli-Papadopoulou T. In Vitro Chondrogenesis Induction by Short Peptides of the Carboxy-Terminal Domain of Transforming Growth Factor β1 Biomedicines. 2023 Nov 29;11(12):3182._x000D_ 4: Santibanez JF, Pérez-Gómez E, Fernandez-L A, Garrido-Martin EM, Carnero A, Malumbres M, Vary CP, Quintanilla M, Bernabéu C. The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras Carcinogenesis. 2010 Dec;31(12):2145-54._x000D_ 5: Lai YT, Beason KB, Brames GP, Desgrosellier JS, Cleggett MC, Shaw MV, Brown CB, Barnett JV. Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation Dev Biol. 2000 Jun 1;222(1):1-11._x000D_ 6: Bhattacharyya S, Chen SJ, Wu M, Warner-Blankenship M, Ning H, Lakos G, Mori Y, Chang E, Nihijima C, Takehara K, Feghali-Bostwick C, Varga J. Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma Am J Pathol. 2008 Oct;173(4):1085-99._x000D_ 7: Harrison CA, Gray PC, Koerber SC, Fischer W, Vale W. Identification of a functional binding site for activin on the type I receptor ALK4 J Biol Chem. 2003 Jun 6;278(23):21129-35._x000D_ 8: Browne JA, Pearson AL, Zahr RA, Niculescu-Duvaz I, Baines DL, Dockrell ME. TGF-beta activates ERK5 in human renal epithelial cells Biochem Biophys Res Commun. 2008 Aug 29;373(3):440-4._x000D_ 9: Ungefroren H, Groth S, Ruhnke M, Kalthoff H, Fändrich F. Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta J Biol Chem. 2005 Jan 28;280(4):2644-52._x000D_ 10: Herrmann J, Borkham-Kamphorst E, Haas U, Van de Leur E, Fraga MF, Esteller M, Gressner AM, Weiskirchen R. The expression of CSRP2 encoding the LIM domain protein CRP2 is mediated by TGF-beta in smooth muscle and hepatic stellate cells Biochem Biophys Res Commun. 2006 Jul 14;345(4):1526-35. _x000D_ _x000D_ Products Related to ALK5 Extracellular Domain Human Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2016873 (50 µg)_x000D_ ALK5 Extracellular Domain Human Recombinant is a high quality type I receptor for transforming growth factor beta (TGF-β) superfamily of proteins. The extracellular domain of ALK5 is the part of the protein that is located outside of the cell and is involved in binding to ligands such as TGF-β. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3