SIRPα Extracellular Domain (human, recombinant)

• Description:

  SIRPα Extracellular Domain (human, recombinant)_x000D_ Catalog number: B2017320_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 µg_x000D_ Molecular Weight or Concentration: 39 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: CD172A, CD172 Antigen-like Family Member A, MyD-1 Antigen, SHPS-1, SHP Substrate 1, Signal Regulatory Protein α_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Vignery A. Osteoclasts and giant cells: macrophage-macrophage fusion mechanism Int J Exp Pathol. 2000 Oct;81(5):291-304._x000D_ 2: Lin Y, Choukrani G, Dubbel L, Rockstein L, Freile JA, Qi Y, Wiersma V, Zhang H, Koch KW, Ammatuna E, Schuringa JJ, van Meerten T, Huls G, Bremer E. VISTA drives macrophages towards a pro-tumoral phenotype that promotes cancer cell phagocytosis yet down-regulates T cell responses Exp Hematol Oncol. 2024 Mar 29;13(1):35._x000D_ 3: Lin Y, Yan XQ, Yang F, Yang XW, Jiang X, Zhao XC, Zhu BK, Liu L, Qin HY, Liang YM, Han H. Soluble extracellular domains of human SIRPα and CD47 expressed in Escherichia coli enhances the phagocytosis of leukemia cells by macrophages in vitro Protein Expr Purif. 2012 Sep;85(1):109-16._x000D_ 4: Nettleship JE, Ren J, Scott DJ, Rahman N, Hatherley D, Zhao Y, Stuart DI, Barclay AN, Owens RJ. Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment BMC Struct Biol. 2013 Jul 4;13:13._x000D_ 5: Lee WY, Weber DA, Laur O, Stowell SR, McCall I, Andargachew R, Cummings RD, Parkos CA. The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47 J Biol Chem. 2010 Dec 3;285(49):37953-63._x000D_ 6: Liu Y, O'Connor MB, Mandell KJ, Zen K, Ullrich A, Bühring HJ, Parkos CA. Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha J Immunol. 2004 Feb 15;172(4):2578-85._x000D_ 7: de Silva S, Fromm G, Shuptrine CW, Johannes K, Patel A, Yoo KJ, Huang K, Schreiber TH. CD40 Enhances Type I Interferon Responses Downstream of CD47 Blockade, Bridging Innate and Adaptive Immunity Cancer Immunol Res. 2020 Feb;8(2):230-245._x000D_ 8: Lin Y, Zhao JL, Zheng QJ, Jiang X, Tian J, Liang SQ, Guo HW, Qin HY, Liang YM, Han H. Notch Signaling Modulates Macrophage Polarization and Phagocytosis Through Direct Suppression of Signal Regulatory Protein α Expression Front Immunol. 2018 Jul 30;9:1744._x000D_ 9: Lee WY, Weber DA, Laur O, Severson EA, McCall I, Jen RP, Chin AC, Wu T, Gernert KM, Parkos CA. Novel structural determinants on SIRP alpha that mediate binding to CD47 J Immunol. 2007 Dec 1;179(11):7741-50._x000D_ 10: Liénard H, Bruhns P, Malbec O, Fridman WH, Daëron M. Signal regulatory proteins negatively regulate immunoreceptor-dependent cell activation J Biol Chem. 1999 Nov 5;274(45):32493-9. _x000D_ _x000D_ Products Related to SIRPα Extracellular Domain (human, recombinant) can be found at Proteins

• Short Description:

  Catalog Number: B2017320 (100 µg)_x000D_ SIRPα (Signal Regulatory Protein Alpha) is a cell surface receptor on myeloid cells, regulating immune cell activation and phagocytosis. The extracellular domain interacts with CD47, inhibiting phagocytosis of healthy cells. The recombinant SIRPα extracellular domain is used in research to study SIRPα-CD47 interactions, drug development, structural studies, and functional assays. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3